SELECTED PUBLICATIONS
ORIGINAL RESEARCH
1) Davis SR, Robinson PJ, Jane F, White S, Brown KA, Piessens S, Edwards A, McNeilage J, Woinarski J, Chipman M, Bell RJ (2018) The benefits of adding metformin to tamoxifen for treatment of hormone receptor positive breast cancer. Accepted in Clinical Endocrinology
2) Zahid H, Subbaramaiah K, Iyengar NM, Zhou ZK, Chen I-C, Bhardwaj P, Gucalp A, Morrow M, Hudis CA, Dannenberg AJ, Brown KA (2018) Leptin regulation of the p53-HIF1a/PKM2-aromatase axis in breast adipose stromal cells - a novel mechanism for the obesity-breast cancer link. Int J Obesity 42(4):711-720
3) Martinez-Chacon G, Brown KA, Docanto MM, Kumar H, Salminen S, Saarinen N, Makela S (2018) IL-10 suppresses the TNFa-induced expression of human aromatase gene in mammary adipose tissue. FASEB J 32(6):3361-3370
4) Toyoda Y, Celie K-B, Xu JT, Buro JS, Jin J, Lin AJ, Brown KA, Spector JS (2018) A 3D biomimetic platform to interrogate the safety of autologous fat transfer in the setting of breast cancer. Annals of Plastic Surgery Apr:80(4 Suppl 4): S223-S228
5) Brown KA*, Iyengar NM, Zhou XK, Gucalp A, Subbaramaiah K, Wang H, Giri DD, Morrow M, Falcone DJ, Wendel NK, Winston LA, Pollak M, Dierickx A, Hudis CA, Dannenberg AJ (2017) Menopause is a determinant of breast aromatase expression and its associations with BMI, inflammation and systemic factors. Accepted in J Clin Endocrinol Metab (*Corresponding author)
6) Iyengar NM, Brown KA, Zhou XK, Gucalp A, Subbaramaiah K, Giri DD, Zahid H, Bhardwaj P, Wendel NK, Falcone DJ, Wang H, Williams S, Pollak M, Morrow M, Hudis CA, Dannenberg AJ (2017) Metabolic Obesity, Adipose Inflammation and Elevated Breast Aromatase in Women with Normal Body Mass Index Cancer Prevention Research, In Press
7) McNamara KM, Oguro S. Omata F, Kikuchi K, Guestini F, Suzuki K, Yang Y, Abe E, Hirakawa H, Brown KA, Takanori I, Ohuchi N, Sasano H (2017) The presence and impact of estrogen metabolism on the biology of triple negative breast cancer. Breast Cancer Research and Treatment 161(2):213-227
8) Au CC, Docanto MM, Zahid H, Raffaelli F, Ferrero RL, Furness JB, Brown KA (2016) Des-acyl ghrelin inhibits the capacity of macrophages to stimulate the expression of aromatase in breast adipose stromal cells. J Steroid Biochem Mol Biol Jul 14, In press.
9) Subbaramaiah K, Brown KA, Zahid H, Balmus G, Weiss RS, Herbert B-S, Dannenberg AJ (2016) Hsp90 and PKM2 drive the expression of aromatase in Li-Fraumeni Syndrome breast adipose stromal cells. JBC, 291 (31), 16011-16023.
10) Ham S, Brown KA, Simpson ER, Meachem SJ (2016) Immunolocalisation of aromatase regulators LKB1, phospho-AMPK and CRTCs in the human testis. Reproduction, Fertility and Development In Press
11) Wang X, Docanto MM, Sasano H, kConFab, Lo C, Simpson ER, Brown KA (2015) Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: A novel mechanism for the regulation of aromatase in obesity and breast cancer. Cancer Research 75 (4), 645-655
12) Huo CW, Chew G, Hill P, Huang D, Ingman W, Hodson L, Brown KA, Magenau A, Allam AH, McGhee E, Timpson P, Henderson MA, Thompson EW, Britt K (2015) High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium. Breast Cancer Research Jun 4; 17:79
13) Lee W, Johnson J, Gough D, Donoghue J, Cagnone G, Vaghjiani V, Brown KA, Johns T, St. John J (2015) DNA methylation of Polymerase Gamma A at exon 2 restricts mitochondrial DNA copy number in cancer cells and prevents differentiation. Cell Death and Disease Feb 26;6:e1664
14) Docanto MM, Ham S, Corbould A, Brown KA (2015) Obesity-associated inflammatory cytokines and prostaglandin E2 stimulate glucose transporter mRNA expression and glucose uptake in primary human adipose stromal cells. Journal of Cytokine and Interferon Research 35(8):600-5
15) Docanto MM, Yang F, Callaghan B, Au CC, Ragavan R, Wang X, Furness JB, Andrews ZB, Brown KA (2014) Ghrelin and des-acyl ghrelin inhibit aromatase expression and activity in human adipose stromal cells: suppression of cAMP as a possible mechanism. Breast Cancer Research and Treatment 147(1), 193-201
16) Lazarus KA, Brown KA, Young M, Zhao Z, Coulson R, Chand AL, Clyne CD (2014) Conditional over-expression of Liver Receptor Homolog -1 in female mouse mammary epithelium results in altered mammary morphogenesis via the induction of TGF-β. Endocrinology 155 (5), 1606-1617
17) McNamara KM, Yoda T, Nurani AM, Shibahara Y, Miki Y, Wang L, Nakamura Y, Suzuki K, Yang Y, Abe E, Hirakawa H, Suzuki T, Nemoto N, Miyashita M, Tamaki K, Ishida T, Brown KA, Ohuchi N, Sasano H (2014) Androgenic pathways in the progression of triple-negative breast carcinoma: a comparison between aggressive and non-aggressive subtypes. Breast Cancer Research and Treatment 145 (2), 281-293
18) Ham S, Meachem SJ, Choong CS, Charles AK, Baynam GS, Jones TW, Samarajeewa NU, Simpson ER, Brown KA (2013) Overexpression of aromatase associated with loss of heterozygosity of the STK11 gene accounts for prepubertal gynecomastia in boys with Peutz Jeghers Syndrome. J Clin Endocrinol Metab 98 (12), E1979-E1987
19) Fukami M, Tsuchiya T, Vollbach H, Brown KA, Abe S, Ohtsu S, Wabitsch M, Burger H, Simpson ER, Umezawa A, Nakabayashi K, Bulun SE, Shozu M, Ogata T (2013) Genomic Basis of Aromatase Excess Syndrome: Recombination- and Replication-Mediated Rearrangements Leading to CYP19A1 Overexpression. J Clin Endocrinol Metab 98 (12), E2013-E2021
20) Samarajeewa NU, Yang F, Docanto MM, Sakurai M, McNamara KM, Sasano H, Fox SB, Simpson ER, Brown KA (2013) HIF-1 alpha stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma. Breast Cancer Research Apr 8; 15(2):R30
21) Samarajeewa NU, Docanto MM, Simpson ER, Brown KA (2013) CREB-regulated transcription co-activator family stimulates promoter II-driven aromatase expression in preadipocytes. Hormones and Cancer 4(4):233-41
22) McInnes KJ*, Brown KA*, Hunger NI, Simpson ER (2012) Regulation of LKB1 expression by Sex Hormones in Adipocytes. International Journal of Obesity 36(7):982-985 (*Joint first authors)
23) Pellatt L, Rice S, Dilaver N, Heshri A, Galea R, Brincat M, Brown K, Simpson ER, Mason HD (2011) Anti-Müllerian hormone reduces follicle sensitivity to follicle-stimulating hormone in human granulosa cells. Fertil Steril 96(5):1246-51
24) Brown KA, McInnes KJ, Takagi K, Ono K, Hunger NI, Wang L, Sasano H, Simpson ER (2011) LKB1 expression is inhibited by estradiol-17β in MCF-7 J Steroid Biochem Mol Biol 127(3-5):439-43
25) Samarajeewa NU, Ham S, Yang F, Simpson ER, Brown KA (2011) Promoter-specific effects of metformin on aromatase transcript expression. Steroids 76:768-771
26) Brown KA, Hunger NI, Docanto M, Simpson ER (2010) Metformin inhibits aromatase expression in human breast stromal cells via stimulation of AMPK. Breast Cancer Research and Treatment.123:591-596
27) Dunbier AK, Hong Y, Masri S, Brown KA, Sabnis GJ, Palomares MR (2010) Progress in aromatase research and identification of key future directions. J Steroid Biochem Mol Biol 118:311-315
28) Brown KA*, McInnes KJ*, Hunger NI, Oakhill J, Steinberg GR, Simpson ER (2009) The Subcellular Localization of CREB-Regulated Transcription Coactivator 2 Provides a Link Between Obesity and Breast Cancer in Postmenopausal Women. Cancer Research 69: 5392-5399 (*Joint first authors)
29) McInnes KJ, Brown KA, Knower KC, Chand AL, Clyne CD, Simpson ER (2008) Characterization of Aromatase Expression in the Human Adipocyte Cell Line SGBS. Breast Cancer Res Treat 112:429-35
INVITED REVIEWS
1) Bhardwaj P, Au CC, Benito-Martin A, Ladumor H, Oshchepkova S, Moges R, Brown KA (2019) Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression. J Steroid Biochem Mol Biol 189:161-170
2) Gérard C, Brown KA (2018) Obesity and breast cancer – role of estrogens and the molecular underpinnings of aromatase regulation in breast adipose tissue. Mol Cell Endocrinol 466:15-30
3) Au CC, Furness JB, Brown KA (2017) Ghrelin and Breast Cancer: Emerging roles in obesity, estrogen regulation and cancer. Frontiers in Oncology 6:265
4) Zahid H, Simpson ER, Brown KA (2016) Inflammation, dysregulated metabolism and aromatase in obesity and breast cancer. Curr Opin Pharmacol 31:90-96
5) Wang X, Simpson ER, Brown KA (2015) p53: protection against tumor growth beyond effects on cell cycle and apoptosis. Cancer Research 75(23), 5001-7
6) Wang X, Simpson ER, Brown KA (2015) Aromatase overexpression in dysfunctional adipose tissue links obesity to postmenopausal breast cancer. Journal of Steroid Biochemistry and Molecular Biology 153:35-44
7) Brown KA, Simpson ER (2015) Estrogens, obesity, inflammation and breast cancer – what is the link? Seminars in Reproductive Medicine 33(3):208-12
8) Brown KA (2014) Impact of obesity on mammary gland inflammation and local estrogen production. Journal of Mammary Gland Biology and Neoplasia 19(2):183-9
9) Simpson ER, Brown KA (2013) Obesity and breast cancer: Role of inflammation and aromatase. J Mol Endocrinol 51 (3), T51-T59
10) Simpson ER, Brown KA (2013) Minireview: Obesity and breast cancer: A tale of inflammation and dysregulated metabolism. Mol Endocrinol 27(5):715-725
11) Brown KA, Samarajeewa NU, Simpson ER (2012) Endocrine-related cancers and the role of AMPK. Mol Cell Endocrinol. 366(2):170-179
12) Brown KA, Simpson ER (2012) Obesity and breast cancer: mechanisms and therapeutic implications. Frontiers in Bioscience 4:2515-24 (22 citations)
13) Haverfield JT, Ham S, Brown KA, Simpson ER, Meachem SJ (2011) Teasing out the role of aromatase in the healthy and diseased testis. Spermatogenesis 1(3):240-249
14) Simpson ER, Brown KA (2011) Obesity, aromatase and breast cancer. Expert Review of Endocrinology & Metabolism 6:383-395
15) Brown KA, Simpson ER (2010) Obesity and breast cancer: progress to understanding the relationship. Cancer Research 70(1):4-7
16) Brown KA, Samarajeewa N (2010) CRTC2 (CREB regulated transcription coactivator 2) Atlas Genet Cytogenet Oncol Haematol 14(12):1104
17) Lovejoy JC, Sainsbury A, the Stock Conference 2008 Working Group (Brown KA, Campbell L, Asarian L, Fried S, Geary N, Marks D, Pasquali R, Pralong FP, Westerterp-Platenga M) (2009) Sex differences in obesity and the regulation of energy homeostasis. Obesity Reviews 10:154-67
BOOK CHAPTERS
1) Brown KA, Simpson ER (2014) Obesity and Breast Cancer: The Role of Dysregulated Estrogen Metabolism Springer brief in Cancer Research 56pp
2) Smith CL, Brown KA, Simpson ER (2012) Regulation of Estrogen Receptor Activity and Aromatase Expression: Roles of Selective Estrogen Receptor Modulators and Metabolic Factors Translational Endocrinology & Metabolism 45-73